Did you know diabetes is the leading cause of chronic kidney disease (CKD) and kidney failure in the United States? A healthy diet and well-controlled blood glucose (sugar) levels can help to extend kidney function in some individuals. However, this tactic may not be for everyone. 

In 2021, the Food and Drug Administration (FDA) approved Kerendia (Finerenone), which may reduce the risk of kidney function decline, kidney failure, and hospitalization for heart failure in adults with CKD associated with type 2 diabetes. Learn more about the efficacy, potential side effects, and who should not take Kerendia.* 

How Effective was Kerendia in Clinical Trials?

To determine the efficacy of Kerendia, researchers recruited 5,674 patients with CKD associated with type 2 diabetes. Participants were randomly assigned to either Kerendia or a placebo. The results found participants taking Kerendia were less likely to have:

• Reduction in kidney function 
• Progression to kidney failure
• Death related to kidney or cardiovascular function
• Non-fatal heart attack
• Non-fatal stroke
• Hospitalization for heart failure

What are the Side Effects of Kerendia?

Like all drugs, there is a chance one may experience side effects. Side effects seen with Kerendia include: 

• Hyperkalemia (high levels of potassium)
• Hypotension (low blood pressure)
• Hyponatremia (low levels of sodium)

Your doctor can discuss if the benefits outweigh the potential risks and side effects by taking into account your health history. Before taking Kerendia, be sure to ask your doctor for signs of these side effects and what to do if they arise. 

Who Should Avoid Kerendia? 

People with adrenal insufficiency, which occurs when the body does not produce enough of certain hormones, and those receiving simultaneous treatment with strong CYP3A4 inhibitors, should not take Kerendia. 

*FDA Approves Drug to Reduce Risk of Serious Kidney and Heart Complications in Adults with Chronic Kidney Disease Associated with Type 2 Diabetes. (2021, July 9). U.S. Food and Drug Administration. https://www.fda.gov/drugs/drug-safety-and-availability/fda-approves-drug-reduce-risk-serious-kidney-and-heart-complications-adults-chronic-kidney-disease